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KMID : 0377619750290010025
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Korean Jungang Medical Journal
1975 Volume.29 No. 1 p.25 ~ p.31
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Studies on the Effect of the Bupleuri Radix on the Serum Transaminase Activities and the Contents of Total Cholesterol in Serum from the Alloxan-diabetic Rabbits
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Abstract
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The effects of root of the Bupleurum falcatum L. on the serum transaminase (SGP-T, SGO-T) activities and the content of total cholesterol in serum from normal and alloxan-diabetic rabbits were observed.
The Bupleuri Radix were extracted with methanol, and the extracted samples were orally administrated to the normal and alloxan-diabetic rabbits.
The blood sugar levels, the amount of total cholesterol in serum and the serum transaminase activities of normal rabbits were significantly increased by intravenous administration of the alloxan 80mg/kg.
The increased serum transaminase activities of the alloxan-diabetic rabbits were significantly decreased after 96 hours by administration of the extracted sample compared to that of control group.
The increased content of total cholesterol in serum of the alloxan-diabetic rabbits were gradually decreased by administration of the extracted samples and returned to the control levels ,after 12 days.
According to the above results, it is concluded that the extract of Bupleuri Radix have influence to the recovery of the increased contents of total cholesterol and serum transaminase activities by alloxan.
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